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Medications and Drugs

Brand Names: Phenergan VC, Promethazine VC Plain

Generic Name: phenylephrine and promethazine (Pronunciation: fen ill EFF rin and pro MEH thah zeen)

What is phenylephrine and promethazine (Phenergan VC, Promethazine VC Plain)?

Phenylephrine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in the sinuses and nose to decrease congestion.

Promethazine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body.

Phenylephrine and promethazine is used to treat symptoms such as itching, runny nose; sneezing; and congestion due to allergies or the common cold.

Phenylephrine and promethazine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of phenylephrine and promethazine (Phenergan VC, Promethazine VC Plain)?

If you experience any of the following serious side effects, stop taking phenylephrine and promethazine and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
  • uncontrollable movements of the eyes, lips, tongue, face, arms, or legs.

Other, less serious side effects may be more likely to occur. Continue to take phenylephrine and promethazine and talk to your doctor if you experience

  • dizziness, drowsiness, sleepiness, or confusion;
  • restlessness or irritability;
  • blurred vision or a dry mouth;
  • nausea or vomiting; or
  • increased skin sensitivity to sunlight.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about phenylephrine and promethazine (Phenergan VC, Promethazine VC Plain)?

Use caution when driving, operating machinery, or performing other hazardous activities. Phenylephrine and promethazine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking phenylephrine and promethazine.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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