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February 10, 2012
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Medications and Drugs

Brand Names: Actos

Generic Name: pioglitazone (oral) (Pronunciation: PYE o GLIT a zone)

What is pioglitazone (Actos)?

Pioglitazone is an oral diabetes medicine that help control blood sugar levels.

Pioglitazone is for people with type 2 (non-insulin-dependent) diabetes. Pioglitazone is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes.

Pioglitazone may also be used for other purposes not listed in this medication guide.

Actos 15 mg

round, white, imprinted with ACTOS, 15

Actos 30 mg

round, white, imprinted with ACTOS, 30

Actos 45 mg

round, white, imprinted with ACTOS, 45

What are the possible side effects of pioglitazone (Actos)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using pioglitazone and call your doctor at once if you have any of these serious side effects:

  • feeling short of breath, even with mild exertion;
  • swelling or rapid weight gain;
  • chest pain, general ill feeling;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • blurred vision;
  • increased thirst or hunger, urinating more than usual; or
  • pale skin, easy bruising or bleeding, weakness.

Continue taking this medication and talk to your doctor if you have any of these less serious side effects:

  • sneezing, runny nose, cough or other signs of a cold;
  • headache;
  • gradual weight gain;
  • muscle pain; or
  • tooth problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pioglitazone (Actos)?

Do not use pioglitazone if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking pioglitazone, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, or liver disease.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a source of sugar available in case you have symptoms of low blood sugar.

Some women using pioglitazone have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

Women may also be more likely than men to have bone fractures in the upper arm, hand, or foot while taking pioglitazone. Talk with your doctor if you are concerned about this possibility.

Taking certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with pioglitazone.


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Brand Names:
Actos
[+]

Generic Name:
pioglitazone (oral)
[+]

Insulin Resistance Overview

Insulin is a hormone that is produced by the beta cells found in the pancreas. Insulin is an important hormone that has many actions within the body including those involved in metabolism (control) of carbohydrates (sugars and starches), lipids (fats), and proteins.

When insulin resistance develops, tissues in the body – particularly muscle and fat tissues- do not respond appropriately to insulin. In fact, more insulin is needed to elicit the same response from these tissues. As a result, higher levels of insulin are needed in order for insulin to continue to exert its physiologic effect.

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There are many causes of insulin resistance, including a strong association with genetics (an inherited component). In addition, insulin resistance is often associated with the following conditions:

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