pioglitazone (oral) (cont.)
What happens if I miss a dose (Actos)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Actos)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. You may have signs of low blood sugar, such as extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
What should I avoid while taking pioglitazone (Actos)?
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
What other drugs will affect pioglitazone (Actos)?
Tell your doctor about all other medicines you use, especially:
- bosentan (Tracleer);
- delavirdine (Rescriptor);
- digoxin (Lanoxin);
- gemfibrozil (Lopid);
- midazolam (Versed);
- morphine (MS Contin, Kadian, Oramorph);
- tolbutamide (Orinase);
- trimethoprim (Proloprim, Primsol, Bactrim, Cotrim, Septra);
- vancomycin (Vancocin, Lyphocin);
- amiloride (Midamor), furosemide (Lasix), or triamterene (Dyrenium);
- cimetidine (Tagamet) or ranitidine (Zantac);
- fluconazole (Diflucan) or ketoconazole (Nizoral);
- nicardipine (Cardene) or nifedipine (Nifedical, Procardia);
- procainamide (Procan, Pronestyl, Procanbid), quinidine (Quin-G), or quinine (Qualaquin);
- rifampin (Rifater, Rifadin, Rifamate) or rifapentine (Priftin);
- a non-steroidal anti-inflammatory drug (NSAID) such as celecoxib (Celebrex), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), mefenamic acid (Ponstel), or piroxicam (Feldene); or
- seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), phenobarbital (Solfoton), primidone (Mysoline), and others.
You may be more likely to have hypoglycemia (low blood sugar) if you take pioglitazone with other drugs that can lower blood sugar, such as:
- probenecid (Benemid);
- some nonsteroidal anti-inflammatory drugs (NSAIDs);
- aspirin or other salicylates (including Pepto-Bismol);
- a blood thinner (warfarin, Coumadin and others);
- heart or blood pressure medication (Accupril, Altace, Lotensin, Prinivil, Vasotec, Zestril, and others);
- sulfa drugs (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others);
- a monoamine oxidase inhibitor (MAOI); or
- other oral diabetes medications, especially acarbose (Precose), metformin (Glucophage), miglitol (Glyset), or rosiglitazone (Avandia).
These lists are not complete and there are many other medicines that can increase or decrease the effects of pioglitazone on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about pioglitazone.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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