piperacillin and tazobactam (cont.)
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What should I discuss with my healthcare provider before using piperacillin and tazobactam (Zosyn)?
You should not use this medication if you are allergic to piperacillin and tazobactam or to any other penicillin antibiotic, such as:
To make sure you can safely use piperacillin and tazobactam, tell your doctor if you have any of these other conditions:
FDA pregnancy category B. Piperacillin and tazobactam is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Piperacillin and tazobactam may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I use piperacillin and tazobactam (Zosyn)?
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Piperacillin and tazobactam is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
Piperacillin and tazobactam must be given slowly, and the IV infusion can take at least 30 minutes to complete.
Piperacillin and tazobactam must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.
Prepare your dose in a syringe, IV bag, or infusion pump only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.
Piperacillin and tazobactam is usually given for 7 to 10 days, depending on the infection being treated. Follow your doctor's instructions.
If you use this medication long-term, your blood will need to be tested often. Visit your doctor regularly.
Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Piperacillin and tazobactam will not treat a viral infection such as the common cold or flu.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using piperacillin and tazobactam.
Store unmixed medicine and the liquid diluent at cool room temperature.
Medicine mixed in an IV bag must be used within 24 hours if you keep it at room temperature.
Mixed medicine in an infusion pump must be used within 12 hours if you keep it at room temperature.
Mixed medication in an IV bag can also be stored in the refrigerator for up to 7 days. Do not freeze. Throw away any unused mixture that has not been used within that time.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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