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Medications and Drugs

Brand Names: Protopam Chloride

Generic Name: pralidoxime (Pronunciation: PRAL i DOX eem)

What is pralidoxime (Protopam Chloride)?

Pralidoxime reverses muscle weakness or paralysis caused by a poison or certain drug overdose.

Pralidoxime is used as an antidote to treat poisoning by a chemical or pesticide (insect spray), or by a drug used to treat a muscle disorder.

This medication is not effective as an antidote for all types of pesticide poisonings.

Pralidoxime may also be used for purposes not listed in this medication guide.

What are the possible side effects of pralidoxime (Protopam Chloride)?

Some of the side effects of pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • fast heart rate;
  • rapid breathing;
  • increased muscle stiffness;
  • a choking feeling;

Less serious side effects may include:

  • pain where the medicine was injected;
  • blurred vision;
  • feeling dizzy or drowsy;
  • headache; or
  • nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about pralidoxime (Protopam Chloride)?

If possible, before you receive pralidoxime, tell your doctor if you have kidney disease, or if you are allergic to any drugs.

Also tell your doctor if you are pregnant or breast-feeding.

In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast-feeding. Make sure any doctor caring for you afterward knows that you have received this medication.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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