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What should I discuss with my doctor before using pramlintide (Symlin, SymlinPen 120, SymlinPen 60)?
Do not use this medication if you are allergic to pramlintide or metacresol. Do not use if you have a digestive condition called "delayed gastric emptying," or if you cannot recognize symptoms of low blood sugar.
If you have any of these other conditions, you may need a pramlintide dose adjustment or special tests:
FDA pregnancy category C. It is not known whether pramlintide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication..
It is not known whether pramlintide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Pramlintide should not be used in children.
How should I use pramlintide (Symlin, SymlinPen 120, SymlinPen 60)?
Use pramlintide exactly as it was prescribed for you. Do not use the medication in larger or smaller amounts, or use it for longer than recommended by your doctor. You may not be able to keep using pramlintide if you do not follow the dosing instructions.
Pramlintide is injected under the skin, at the same time as your insulin injection but in a separate syringe or injector pen. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Do not mix pramlintide and insulin together in the same syringe.
Use only the syringe or injection pen recommended by your doctor. Ask your pharmacist about which needles to buy for proper use of the syringe or injection pen.
Pramlintide is usually given just before each major meal. Follow your doctor's instructions. If you skip a meal, do not take your dose of pramlintide. Wait until your next meal.
Pramlintide should be at room temperature when you inject it.
Use a different place on your stomach or thigh each time you give the injection. Inject your insulin in a separate skin area. Do not inject insulin or pramlintide into the same place two times in a row. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.
Use a disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Call your doctor if you have severe nausea that lasts for several days. This may be a sign that your dose is too high.
If you stop using pramlintide for a short time, you may need to restart the medication at a lower dose. Follow your doctor's instructions.
You will need to use a lower dose of insulin than you used before you started using pramlintide. Your doctor will determine the correct insulin dose based on the type of diabetes you have.
Do not change your doses or medication schedule without your doctor's advice. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.
Take care not to let your blood sugar get too low, causing hypoglycemia. Severe hypoglycemia may occur within 3 hours after your pramlintide injection. Symptoms include headache, hunger, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Be sure your family and close friends know how to help you in an emergency.
Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.
Do not freeze pramlintide, and throw away the medication if it has become frozen.
Storing after your first use: You may keep "in-use" vials or injection pens in the refrigerator or at room temperature. Use within 30 days.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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