What happens if I miss a dose (Matulane)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Matulane)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe nausea and vomiting, tremors, or seizure (convulsions).
What should I avoid while taking procarbazine (Matulane)?
Do not drink alcohol. Procarbazine can cause unpleasant side effects when you drink alcohol.
Avoid smoking during your treatment. Smoking may increase your risk of lung cancer while taking procarbazine.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Do not receive a "live" vaccine while using procarbazine. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), oral polio, typhoid, chickenpox (varicella), BCG (Bacillus Calmette and Guérin), and nasal flu vaccine.
While you are taking procarbazine, you should avoid foods that are high in tyramine, including:
- avocados, bananas, figs, papaya, raisins, and sauerkraut;
- beef or chicken liver, meats prepared with tenderizer, bologna, pepperoni, summer sausage, game meat, meat extracts;
- pickled or smoked fish, anchovies, dried fish, herring, caviar, shrimp paste;
- beer (alcoholic and nonalcoholic), wine (especially red wine), champagne, sherry, vermouth, and other distilled spirits;
- caffeine (including coffee, tea, cola), ginseng;
- cheese -- especially aged or processed cheeses (American, blue, boursault, brie, camembert, cheddar, gruyere, mozzarella, parmesan, romano, roquefort, Swiss);
- sour cream and yogurt;
- soy sauce, miso soup, bean curd, fava beans; or
- yeast extracts.
Eating tyramine while you are taking procarbazine can raise your blood pressure to dangerous levels, causing life-threatening side effects.
What other drugs will affect procarbazine (Matulane)?
Before taking procarbazine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They may increase certain side effects of procarbazine.
Tell your doctor about all other medicines you use, especially:
- blood pressure medication;
- an antidepressant such as amitriptyline (Elavil, Vanatrip), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), and others;
- a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
- diet pills, stimulants, or ADHD medication such as Adderall or Ritalin; or
- phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), promethazine (Pentazine, Phenergan, Anergan, Antinaus), thioridazine (Mellaril), or trifluoperazine (Stelazine).
This list is not complete and other drugs may interact with procarbazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your doctor or pharmacist can provide more information about procarbazine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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