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Medications and Drugs

Brand Names: Vivactil

Generic Name: protriptyline (Pronunciation: proe TRIP ti leen)

What is protriptyline (Vivactil)?

Protriptyline is a tricyclic antidepressant. Protriptyline affects chemicals in the brain that may become unbalanced.

Protriptyline is used to treat symptoms of depression.

Protriptyline may also be used for purposes not listed in this medication guide.

What are the possible side effects of protriptyline (Vivactil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • a feeling that you might pass out;
  • new or worsening chest pain, pounding heartbeats or fluttering in your chest;
  • sudden numbness or weakness, problems with vision, speech, or balance;
  • fever;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • confusion, hallucinations, unusual thoughts or behavior;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • painful or difficult urination;
  • seizure (convulsions); or
  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • tingly feeling, weakness, lack of coordination;
  • nausea, vomiting, loss of appetite, constipation, diarrhea;
  • dry mouth, blurred vision, ringing in your ears;
  • breast swelling (in men or women); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about protriptyline (Vivactil)?

You should not take this medication if you have recently had a heart attack, or if you are allergic to protriptyline or to similar antidepressants such as amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, or trimipramine.

Do not use protriptyline if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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Use the pill finder tool on RxList.



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