What happens if I miss a dose (Vivactil)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Vivactil)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of protriptyline can be fatal.
What should I avoid while taking protriptyline (Vivactil)?
Do not drink alcohol. Protriptyline can increase the effects of alcohol, which could be dangerous.
Grapefruit and grapefruit juice may interact with protriptyline and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid exposure to sunlight or tanning beds. Protriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
What other drugs will affect protriptyline (Vivactil)?
Taking protriptyline with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking protriptyline with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Before taking protriptyline, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline.
You must wait at least 5 weeks after stopping fluoxetine (Prozac) before you can take protriptyline.
Many drugs can interact with protriptyline. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with protriptyline, especially:
- St. John's wort;
- any other anti-depressant, or medication to treat mental illness;
- bladder or urinary medicines such as darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;
- bronchodilators such as ipratropium or tiotropium;
- cold or allergy medicine that contains an antihistamine;
- medication for Parkinson's disease;
- medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;
- a decongestant (pseudoephedrine, phenylephrine), diet pills, stimulant medication; or
- the heart rhythm medications flecainide, propafenone, or quinidine.
This list is not complete and many other drugs can interact with protriptyline. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist has information about protriptyline written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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