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What should I discuss with my health care provider before I receive retaplase (Retavase)?

You should not receive this medication if you are allergic to retaplase, or if you have certain conditions. Be sure your doctor knows if you have:

• any active bleeding;
• a bleeding or blood clotting disorder;
• a brain tumor, aneurysm, or blood vessel disorder;
• untreated or uncontrolled high blood pressure;
• a history of stroke or blood clot; or
• recent spine or brain injury or surgery.

Before you receive retaplase, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• liver disease;
• eye complications caused by diabetes;
• an infection of the lining of your heart (also called bacterial endocarditis); or
• if you have had any recent surgery, injury, or major bleeding.

If you have any of these conditions, you may need a dose adjustment or special tests to safely receive this medicaiton.

FDA pregnancy category C. Retaplase may be harmful to an unborn baby. Before receiving this medication, tell your doctor if you are pregnant.

It is not known whether retaplase passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is retaplase given (Retavase)?

Retaplase is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

Retaplase is usually given in two quick injections through an IV line. These injection are given 30 minutes apart.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you have received retaplase.

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