What happens if I miss a dose (Rilutek)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Rilutek)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking riluzole (Rilutek)?
Riluzole may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid drinking alcohol. It may increase your risk of liver damage.
Avoid coffee, tea, cola, or other products that contain caffeine. Caffeine may cause too much riluzole to build up in your body.
Avoid smoking. Smoking cigarettes may make riluzole less effective.
What other drugs will affect riluzole (Rilutek)?
Many drugs can interact with riluzole. Below is just a partial list. Tell your doctor if you are using:
- acetaminophen (Tylenol);
- allopurinol (Zyloprim);
- amitriptyline (Elavil, Vanatrip);
- auranofin (Ridaura);
- cancer medications
- methyldopa (Aldomet);
- omeprazole (Prilosec);
- sulfasalazine (Azulfidine);
- theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl, and others);
- tuberculosis medications;
- birth control pills or other hormones;
- methotrexate (Rheumatrex, Trexall);
- an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
- an antibiotic such as ciprofloxacin (Cipro), dapsone, erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), levofloxacin (Levaquin), norfloxacin (Noroxin), ofloxacin (Floxin), or rifampin (Rifater, Rifadin, Rifamate);
- antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
- cholesterol medications such as niacin (Advicor, Niaspan, Niacor, Slo-Niacin, and others), atorvastatin (Lipitor), simvastatin (Zocor, Simcor, Vytorin), lovastatin (Mevacor), pravastatin (Pravachol), and others;
- HIV/AIDS medications such as abacavir/lamivudine/zidovudine (Trizivir), lamivudine (Combivir, Epivir), nevirapine (Viramune), tenofovir (Viread), or zidovudine (Retrovir);
- an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others; or
- seizure medications such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), felbamate (Felbatol), valproic acid (Depakene).
This list is not complete and there are many other drugs that can interact with riluzole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about riluzole.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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