What happens if I miss a dose (Xarelto)?
Take the missed dose as soon as you remember. Take your next dose the following day and stay on your once-daily schedule. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Xarelto)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose may cause excessive bleeding.
What should I avoid while taking rivaroxaban (Xarelto)?
Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
What other drugs will affect rivaroxaban (Xarelto)?
Tell your doctor about all other medicines you use, especially:
- bosentan (Tracleer);
- conivaptan (Vaprisol);
- dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
- rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);
- St. John's wort;
- quinidine (Quin-G);
- verapamil (Calan, Covera, Isoptin, Verelan);
- an antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin) or erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole);
- antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
- a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
- heart or blood pressure medication such as reserpine, amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), dronedarone (Multaq), felodipine (Plendil), quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan);
- HIV medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, Kaletra), or saquinavir (Invirase);
- medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil);
- medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune) or tacrolimus (Prograf); or
- seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).
Many other drugs (including some over-the-counter medicines) can increase your risk of bleeding, and it is very important to tell your doctor about all medicines you have recently used. Bleeding or blood clots around the brain or spinal cord may occur if you use rivaroxaban with other drugs that can affect blood clotting, such as:
- abciximab (ReoPro), eptifibatide (Integrelin), tirofiban (Aggrastat);
- cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), prasugrel (Effient), ticlopidine (Ticlid);
- dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, tinzaparin (Innohep)warfarin (Coumadin, Jantoven);
- argatroban (Acova), bivalirudin (Angiomax), lepirudin (Refludan);
- alteplase (Activase), tenecteplase (TNKase), urokinase (Abbokinase);
- an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
- salicylates such as Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others.
This list is not complete and other drugs may interact with rivaroxaban. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about rivaroxaban.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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