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What should I discuss with my healthcare provider before taking roflumilast (Daliresp)?

You should not use roflumilast if you are allergic to it, or if you have moderate or severe liver disease.

There are many other drugs that can make roflumilast less effective and should not be used at the same time. This includes:

• bosentan (Tracleer);
• dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
• St. John's wort;
• rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);
• a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton);
• HIV medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra);
• medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or
• seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).

To make sure you can safely take roflumilast, tell your doctor if you have any of these other conditions:

• liver disease;
• a history of depression, mental illness, or suicidal thoughts or actions.

You may have unusual thoughts or behavior, or thoughts about suicide, while taking this medicine. Tell your doctor if you have new or worsening depression, or suicidal thoughts. Your family or other caregivers should also be alert to changes in your mood or symptoms.

FDA pregnancy category C. It is not known whether roflumilast will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Roflumilast can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using roflumilast.

Do not give this medication to anyone under 18 years old without medical advice. Do not share this medication with other people, even if they have the same symptoms you have.

How should I take roflumilast (Daliresp)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Roflumilast is usually taken once per day, with or without food. Follow your doctor's instructions.

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