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Medications and Drugs

Brand Names: Natrol SAMe

Generic Name: s-adenosylmethionine (SAMe) (Pronunciation: S - a DEE noe SIL meth EYE oh neen)

What is s-adenosylmethionine (SAMe) (Natrol SAMe)?

S-adenosylmethionine is a naturally occurring chemical in the body.

S-adenosylmethionine (also called SAMe) has been used in alternative medicine as an aid to treating depression, osteoarthritis, fibromyalgia, and liver problems.

Not all uses for SAMe have been approved by the FDA. SAMe should not be used in place of medication prescribed for you by your doctor.

SAMe is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

S-adenosylmethionine may also be used for purposes not listed in this product guide.

What are the possible side effects of s-adenosylmethionine (Natrol SAMe)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about s-adenosylmethionine (SAMe) (Natrol SAMe)?

You should not use this product if you are allergic to s-adenosylmethionine.

Do not use SAMe if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Not all uses for SAMe have been approved by the FDA. SAMe should not be used in place of medication prescribed for you by your doctor.

SAMe is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Do not use this product without medical advice if you are pregnant or breast-feeding



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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