Medications and Drugs

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Brand Names: Renagel, Renvela

Generic Name: sevelamer (Pronunciation: se VEL a mer)

• What is sevelamer (Renagel, Renvela)?
• What are the possible side effects of sevelamer (Renagel, Renvela)?
• What is the most important information I should know about sevelamer (Renagel, Renvela)?
• What should I discuss with my healthcare provider before taking sevelamer (Renagel, Renvela)?
• How should I take sevelamer (Renagel, Renvela)?
• What happens if I miss a dose (Renagel, Renvela)?
• What happens if I overdose (Renagel, Renvela)?
• What should I avoid while taking sevelamer (Renagel, Renvela)?
• What other drugs will affect sevelamer (Renagel, Renvela)?
• Where can I get more information?

What is sevelamer (Renagel, Renvela)?

Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus.

Sevelamer is used to reduce blood levels of phosphorus in people with chronic kidney disease who are on dialysis.

Sevelamer may also be used for other purposes not listed in this medication guide.

What are the possible side effects of sevelamer (Renagel, Renvela)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• severe stomach pain or constipation; or
• fever, chills, body aches, flu symptoms.

Less serious side effects may include:

• upset stomach;
• stomach pain, gas;
• nausea, vomiting;
• diarrhea; or
• constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about sevelamer (Renagel, Renvela)?

You should not take this medication if you are allergic to sevelamer, or if you have a low blood level of phosphorus (hypophosphatemia), or a blockage in your intestines.

Before taking sevelamer, tell your doctor if you have trouble swallowing, severe constipation, a digestive disorder of your stomach or intestines, or if you have recently had stomach or intestinal surgery.

Avoid taking any other medicines within 1 hour before or 3 hours after you take sevelamer. Sevelamer can bind to other medications and make them less effective.

Before taking sevelamer, tell your doctor if you are taking ciprofloxacin (Cipro), a heart rhythm medication, or a seizure medication.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends.