Medications and Drugs

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Brand Names: Renagel, Renvela

Generic Name: sevelamer (Pronunciation: se VEL a mer)

• What is sevelamer (Renagel, Renvela)?
• What are the possible side effects of sevelamer (Renagel, Renvela)?
• What is the most important information I should know about sevelamer (Renagel, Renvela)?
• What should I discuss with my healthcare provider before taking sevelamer (Renagel, Renvela)?
• How should I take sevelamer (Renagel, Renvela)?
• What happens if I miss a dose (Renagel, Renvela)?
• What happens if I overdose (Renagel, Renvela)?
• What should I avoid while taking sevelamer (Renagel, Renvela)?
• What other drugs will affect sevelamer (Renagel, Renvela)?
• Where can I get more information?

What is sevelamer (Renagel, Renvela)?

Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus.

Sevelamer is used to reduce blood levels of phosphorus in people with chronic kidney disease who are on dialysis.

Sevelamer may also be used for purposes not listed in this medication guide.

Renagel 400 mg

oval, white, imprinted with RENAGEL 400

Renagel 800 mg

oval, white, imprinted with RENAGEL 800

Renvela 800 mg

oval, white, imprinted with Renvela 800

What are the possible side effects of sevelamer (Renagel, Renvela)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using sevelamer and call your doctor at once if you have a serious side effect such as:

• black, bloody, or tarry stools;
• constipation that gets worse or does not clear up;
• severe constipation with stomach pain; or
• fever, chills, body aches, flu symptoms.

Less serious side effects may include:

• nausea, vomiting, stomach pain, loss of appetite;
• upset stomach, gas, bloating;
• diarrhea, mild constipation;
• tired feeling;
• itching; or
• joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about sevelamer (Renagel, Renvela)?

You should not take this medication if you are allergic to sevelamer, or if you have a bowel obstruction.

Before taking sevelamer, tell your doctor if you have trouble swallowing, severe constipation, a blockage in your intestines, a stomach or intestinal disorder, or if you have recently had stomach or intestinal surgery.

Avoid taking any other medicines within 1 hour before or 3 hours after you take sevelamer. Sevelamer can bind to other medications and make them less effective.

Before taking sevelamer, tell your doctor if you are taking ciprofloxacin (Cipro), a heart rhythm medication, or a seizure medication.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends.

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