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What should I discuss with my health care provider before receiving sipuleucel-T (Provenge)?
Before you are treated with sipuleucel-T, tell your doctor about all of your medical conditions.
If you have any of these conditions, you may need a sipuleucel-T dose adjustment or special tests:
How is sipuleucel-T given (Provenge)?
Approximately 3 days before you receive this medication, your immune cells will be collected with a procedure called leukapheresis (LOO-ka-fe-REE-sis).
During the leukapheresis procedure, your immune cells will be collected through a small tube (catheter) placed into a vein in each of your arms. If the veins in your arms cannot be used, the catheter will be placed into a vein in your neck or upper chest.
The cell-collection catheter is connected to a machine that draws out your blood and separates your immune cells from other parts of the blood.
The cell collection process can take up to 4 hours to complete.
The collected immune cells are then mixed with sipuleucel-T, which contains a special protein that helps activate your body's immune cells. When injected back into your, these activated immune cells may be able to "recognize" and attack certain prostate cancer cells.
Your prepared sipuleucel-T solution will be injected into a vein through an IV. You will receive this injection in a clinic or hospital setting approximately 3 days after your cell collection procedure. Sipuleucel-T must be given slowly, and the IV infusion can take about 60 minutes to complete.
Your doctor will determine your schedule for cell collection and sipuleucel-T injection. Follow your doctor's instructions very carefully. The timing of cell collection in relation to sipuleucel-T infusion is extremely important. If you miss an infusion appointment your prepared infusion cannot be used in the future.
Sipuleucel-T is usually given in 3 doses spaced 2 weeks apart. Follow your doctor's instructions.
You will be given oral medications before your IV infusion to help prevent certain side effects.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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