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What should I discuss with my doctor before taking sirolimus (Rapamune)?
Sirolimus may increase your risk of developing lymphoma or other forms of cancer. Talk with your doctor about your specific cancer risk.
You should not use this medication if you are allergic to sirolimus.
To make sure you can safely take sirolimus, tell your doctor if you have any of these other conditions:
FDA pregnancy category C. It is not known whether sirolimus will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends.
It is not known whether sirolimus passes into breast milk or if it could harm a nursing baby. You should not breast-feed while taking sirolimus.
This medicine should not be given to a child younger than 13 years old.
How should I take sirolimus (Rapamune)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
Take the sirolimus tablet with a full glass of water.
Do not crush, chew, or break a sirolimus tablet. Tell your doctor if you have trouble swallowing the tablet whole.
You may take sirolimus with or without food, but take it the same way every time.
The oral liquid (solution) comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
The oral liquid must be mixed with at least 2 ounces (1/4 cup) of water or orange juice. Do not use any other liquids to mix this medicine.
Stir the mixture and drink all of it right away. Then add at least 4 ounces (1/2 cup) more water or orange juice to the same glass, stir again and drink right away.
Sirolimus is usually taken once a day. If you also take cyclosporine, wait at least 4 hours after your cyclosporine dose before you take sirolimus.
Sirolimus can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly.
Avoid getting sirolimus liquid on your skin or around your nose. If it does get onto any of these areas, wash with soap and water. If this medicine gets into your eyes, rinse them with plain water.
Store sirolimus tablets at room temperature, away from heat, moisture, and light.
Store sirolimus oral liquid in the refrigerator. Do not freeze. You may notice a slight haze to the liquid after it has been refrigerated. This haze will not affect the medication, and should disappear when the medicine reaches room temperature.
If you are taking Rapamune oral liquid with a disposable syringe, you may store a loaded syringe in the carrying case provided. Keep the case at room temperature and use the medicine within 24 hours. Use a disposable syringe only once and then throw it away.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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