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sorafenib (cont.)

What should I discuss with my health care provider before taking sorafenib (Nexavar)?

You should not use sorafenib if you are allergic to it, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

To make sure you can safely take sorafenib, tell your doctor if you have any of these other conditions:

  • kidney or liver problems other than cancer;
  • lung cancer, especially if you are receiving gemcitabine (Gemzar) and cisplatin (Platinol);
  • a bleeding or blood clotting disorder such as hemophilia;
  • high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain;
  • a personal or family history of Long QT syndrome;
  • a history of stroke or heart attack; or
  • any allergies.

FDA pregnancy category D. Do not use sorafenib if you are pregnant. It could harm the unborn baby. Use effective birth control while you are using this medication and for at least 2 weeks after your treatment ends, whether you are a man or a woman. Sorafenib use by either parent may cause birth defects.

It is not known whether sorafenib passes into breast milk or if it could harm a nursing baby. Do not breast-feed while using this medication.

How should I take sorafenib (Nexavar)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take sorafenib on an empty stomach, at least 1 hour before or 2 hours after eating.

Do not crush, chew, or break a sorafenib tablet. Swallow it whole with water.

To be sure this medication is not causing harmful side effects, your blood pressure will need to be checked often. Visit your doctor regularly.

If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are taking sorafenib. You may need to stop taking the medicine for a short time.

Store at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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