What happens if I miss a dose (Nexavar)?
Take the missed dose as soon as you remember, but at least 2 hours since your last meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Nexavar)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe diarrhea or severe skin rash.
What should I avoid while taking sorafenib (Nexavar)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What other drugs will affect sorafenib (Nexavar)?
Tell your doctor about all other cancer medicines you use, especially cyclophosphamide (Cytoxan, Neosar), docetaxel (Taxotere), doxorubicin (Adriamycin, Rubex), fluorouracil (Adrucil, Carac, Efudex, Fluoroplex), irinotecan (Camptosar), paclitaxel (Taxol) or tamoxifen (Soltamox).
The following drugs can interact with sorafenib. Tell your doctor if you are using any of these:
- a blood thinner such as warfarin (Coumadin);
- bosentan (Tracleer);
- dexamethasone (Decadron, Hexadrol);
- montelukast (Singulair) or zafirlukast (Accolate);
- neomycin (Mycifradin, Neo Fradin, Neo Tab);
- promethazine (Phenergan, Adgan, Anergan, Antinaus, Pentazine);
- rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);
- selegiline (Eldepryl, Emsam, Zelapar);
- St. John's wort;
- voriconazole (Vfend);
- an antidepressant such as bupropion (Wellbutrin), fluoxetine (Prozac);
- a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal);
- heart or blood pressure medications such as amiodarone (Cordarone, Pacerone), carvedilol (Coreg), losartan (Hyzaar, Cozaar), or torsemide (Demadex);
- HIV medication such as efavirenz (Sustiva), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir);
- medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil);
- seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), fosphenytoin (Cerebyx), oxcarbazepine (Trileptal), phenytoin (Dilantin), phenobarbital (Luminal, Solfoton), or primidone (Mysoline);
- sulfa drugs (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others); or
- type 2 diabetes medications such as glimepiride (Amaryl), glipizide (Glucotrol), nateglinide (Starlix), pioglitazone (Actos, Actoplus Met), repaglinide (Prandin), rosiglitazone (Avandia, Avandamet), or tolbutamide (Orinase).
This list is not complete and other drugs may interact with sorafenib. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about sorafenib.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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