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sumatriptan and naproxen (cont.)

What should I discuss with my health care provider before taking sumatriptan and naproxen (Treximet)?

You should not use this medication if you are allergic to sumatriptan (Imitrex), naproxen (Aleve, Anaprox, Naprosyn), or if you have a history of asthma or allergic reaction caused by aspirin or other NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others.

Do not take sumatriptan and naproxen if you have:

  • liver disease;
  • untreated or uncontrolled high blood pressure; or
  • a history of heart disease, angina (chest pain), blood circulation problems, heart attack, stroke, or heart bypass surgery (also called coronary artery bypass graft, or CABG).

Do not take sumatriptan and naproxen if you have taken a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the past 14 days.

Do not take sumatriptan and naproxen within 24 hours before or after taking any of the following medicines:

  • almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), sumatriptan (Imitrex), or zolmitriptan (Zomig); or
  • ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).

To make sure you can safely take sumatriptan and naproxen, tell your doctor if you have any of these other conditions:

FDA pregnancy category C. Taking naproxen during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Sumatriptan and naproxen can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medication.

How should I take sumatriptan and naproxen (Treximet)?

Use exactly as prescribed by your doctor. Follow the directions on your prescription label. Never use more than the recommended dose. Overuse of migraine headache medicine can actually make your headaches worse. Tell your doctor if the medicine seems to stop working as well.

Take one (1) sumatriptan and naproxen tablet as soon as you notice headache symptoms, or after an attack has already begun. You may take the medicine with or without food.

Do not crush, chew, or break the tablet. Swallow the pill whole.

After taking a tablet: If your headache does not completely go away, or goes away and comes back, you may take a second tablet two (2) hours after the first.

You must wait at least 2 hours before taking a second tablet. Do not take more than 2 sumatriptan and naproxen tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.

Contact your doctor if you have more than five headaches in one month (30 days).

Naproxen can cause unusual results with certain medical tests. Tell any doctor who treats you if you have taken sumatriptan and naproxen within the past 72 hours.

Store at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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