What should I discuss with my doctor before receiving temsirolimus (Torisel)?

You should not use this medication if you are allergic to temsirolimus or if you have severe liver disease.

To make sure you can safely receive temsirolimus, tell your doctor if you have any of these other conditions:

• liver disease;
• high cholesterol or triglycerides (a type of fat in the blood);
• diabetes;
• a history of head injury, stroke, or brain tumor; or
• if you are allergic to sirolimus (Rapamune).

FDA pregnancy category D. Do not use temsirolimus if you are pregnant. It could harm the unborn baby. Use effective birth control while you are using this medication and for at least 3 months after your treatment ends.

If a man fathers a child while using this medication, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Continue using condoms for at least 3 months after you stop using temsirolimus.

It is not known whether temsirolimus passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using temsirolimus.

How is temsirolimus given (Torisel)?

Temsirolimus is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Temsirolimus must be given slowly, and the IV infusion can take up to 60 minutes to complete.

Temsirolimus is usually given once each week unless your cancer progresses or you have serious side effects from the medication.

You may receive other medications before your temsirolimus infusion. These medications will help prevent certain side effects.

Temsirolimus can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Your kidney function may also need to be tested. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using temsirolimus. You may need to stop using the medicine for a short time.

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