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Brand Names: Thioplex

Generic Name: thiotepa (Pronunciation: THYE oh TEP a)

• What is thiotepa (Thioplex)?
• What are the possible side effects of thiotepa (Thioplex)?
• What is the most important information I should know about thiotepa (Thioplex)?
• What should I discuss with my healthcare provider before using thiotepa (Thioplex)?
• How should I use thiotepa (Thioplex)?
• What happens if I miss a dose (Thioplex)?
• What happens if I overdose (Thioplex)?
• What should I avoid while using thiotepa (Thioplex)?
• What other drugs will affect thiotepa (Thioplex)?
• Where can I get more information?

What is thiotepa (Thioplex)?

Thiotepa is a cancer (antineoplastic) medication. Thiotepa interferes with the growth of cancer cells and slows their growth and spread in the body.

Thiotepa is used in the treatment of cancers of the breast, ovary, bladder, and others.

Thiotepa may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of thiotepa (Thioplex)?

If you experience any of the following serious side effects from thiotepa, seek emergency medical attention or contact your doctor immediately:

• an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
• decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);
• tissue or vein reactions near the site of administration;
• liver damage (abdominal pain, yellowing of the skin or eyes);
• severe nausea, vomiting, or loss of appetite;
• fever, chills, or other signs of infection; or
• painful or difficult urination.

Other, less serious side effects may be more likely to occur. Continue taking thiotepa and talk to your doctor if you experience:

• fatigue or weakness;
• mild to moderate nausea, vomiting, or loss of appetite;
• redness or inflammation of the eyes;
• dizziness, headache, or blurred vision;
• temporary hair loss;
• a loss of skin coloration; or
• decreased menstruation in women and decreased sperm production in men.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about thiotepa (Thioplex)?

Thiotepa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of thiotepa including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); severe heart damage with prolonged use; decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection); severe nausea, vomiting, diarrhea, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with thiotepa.

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