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What should I discuss with my healthcare provider before using thiotepa (Thioplex)?

Do not use thiotepa without first talking to your doctor if you have

• kidney disease;
• liver disease; or
• poor bone marrow function.

The use of thiotepa may be dangerous if you have any of the conditions listed above.

Thiotepa is in the FDA pregnancy category D. This means that thiotepa is known to be harmful to an unborn baby. Do not use thiotepa without first talking to your doctor if you are pregnant. Discuss with your doctor the appropriate use of birth control during treatment with thiotepa if either you or your partner is of childbearing potential.

It is not known whether thiotepa passes into breast milk. Do not take thiotepa without first talking to your doctor if you are breast-feeding a baby.

The safety and effectiveness of thiotepa in children has not been established.

How should I use thiotepa (Thioplex)?

Thiotepa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with thiotepa depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with thiotepa to monitor progress and side effects.

Skin accidentally exposed to thiotepa should be rinsed thoroughly with soap and warm water.

Your healthcare provider will store thiotepa as directed by the manufacturer. If you are storing thiotepa at home, follow the directions provided by your healthcare provider.

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