Medications and Drugs

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Brand Names: Innohep

Generic Name: tinzaparin (Pronunciation: tin ZA pa rin)

• What is tinzaparin (Innohep)?
• What are the possible side effects of tinzaparin (Innohep)?
• What is the most important information I should know about tinzaparin (Innohep)?
• What should I discuss with my healthcare provider before using tinzaparin (Innohep)?
• How should I use tinzaparin (Innohep)?
• What happens if I miss a dose (Innohep)?
• What happens if I overdose (Innohep)?
• What should I avoid while using tinzaparin (Innohep)?
• What other drugs will affect tinzaparin (Innohep)?
• Where can I get more information?

What is tinzaparin (Innohep)?

Tinzaparin is an anticoagulant (blood thinner) that prevents the formation of blood clots.

Tinzaparin is used together with warfarin (Coumadin) to treat a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism).

Tinzaparin may also be used for other purposes not listed in this medication guide.

What are the possible side effects of tinzaparin (Innohep)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tinzaparin and call your doctor at once if you have a serious side effect such as:

• unusual bleeding (nose, mouth, vagina, or rectum), bleeding from wounds or needle injections, any bleeding that will not stop;
• easy bruising, purple or red pinpoint spots under your skin;
• pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
• black or bloody stools, coughing up blood or vomit that looks like coffee grounds;
• numbness, tingling, or muscle weakness (especially in your legs and feet);
• loss of movement in any part of your body;
• sudden weakness, severe headache, confusion, or problems with speech, vision, or balance;
• chest pain; or
• pain or burning when you urinate.

Less serious side effects may include:

• mild headache, dizziness;
• back pain;
• fever;
• pain, irritation, swelling, or bruising of the skin where the medicine was injected;
• nausea, vomiting, stomach pain, gas;
• diarrhea, constipation;
• mild skin rash; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tinzaparin (Innohep)?

You should not use this medication if you are allergic to tinzaparin, heparin, sulfites, benzyl alcohol, or pork products, or if you have active bleeding or a history of low platelet counts after receiving heparin.

Tinzaparin may cause you to bleed more easily, especially if you have: a bleeding disorder, hemorrhagic stroke, an infection in the lining of your heart, uncontrolled high blood pressure, stomach or intestinal bleeding or ulcer, kidney disease, liver failure, amyloidosis (a build-up of certain proteins in tissues and organs of the body), or if you have had recent brain, spine, or eye surgery.

Many other drugs (including some over-the-counter medicines) can increase your risk of bleeding or life-threatening blood clots, and it is very important to tell your doctor about all medicines you have recently used.

Blood clots around the brain or spinal cord may occur if you use tinzaparin with other drugs that can affect blood clotting, including aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) such as Advil or Motrin, and any other medications to treat or prevent blood clots.

Tell your caregivers at once if you have signs of bleeding such as black or bloody stools, coughing up blood, confusion, feeling like you might pass out, or any bleeding that will not stop.

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