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What happens if I miss a dose (Aggrastat)?

Since tirofiban is usually given in a hospital or clinic setting as needed, it is not likely that you will miss a dose.

What happens if I overdose (Aggrastat)?

Seek emergency medical attention if you think you have received too much of this medicine.

Symptoms of a tirofiban overdose may include vomiting, feeling exhausted or short of breath, and severe bleeding.

What should I avoid while receiving tirofiban (Aggrastat)?

While you are receiving tirofiban, do not take aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) without your doctor's advice. NSAIDs include ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.

Tirofiban lowers blood cells that help your blood clot. This can make it easier for you to bruise or bleed from an injury or minor cut. Avoid activities that increase your risk of a bruising or bleeding injury. Use extra caution to avoid cuts when brushing your teeth or shaving.

Avoid drinking alcohol while receiving tirofiban. Alcohol may increase your risk of bleeding in your stomach or intestines.

What other drugs will affect tirofiban (Aggrastat)?

Before receiving tirofiban, tell your doctor if you are using any of the following drugs:

• phenytoin (Dilantin);
• tamoxifen (Nolvadex);
• tolbutamide (Orinase);
• torsemide (Demadex);
• fluvastatin (Lescol);
• a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); or
• any other medications used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

If you are using any of these drugs, you may not be able to receive tirofiban, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect tirofiban. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist has information about tirofiban written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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