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Medications and Drugs

Brand Names: Tolinase

Generic Name: tolazamide (Pronunciation: tole AZ a mide)

What is tolazamide (Tolinase)?

Tolazamide is an oral diabetes medicine that helps control blood sugar levels. This medication helps your body respond better to insulin produced by your pancreas.

Tolazamide is used together with diet and exercise to treat type 2 diabetes. Other diabetes medicines are sometimes used in combination with tolazamide if needed.

Tolazamide may also be used for purposes not listed in this medication guide.

Tolazamide 250 mg-MYL

round, white, imprinted with 250, MYLAN 217

Tolazamide 250 mg-ZEN

round, white, imprinted with Z 2979

Tolazamide 500 mg-MYL

round, white, imprinted with MYLAN 551

What are the possible side effects of tolazamide (Tolinase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hypoglycemia, or low blood sugar, is the most common side effect of tolazamide. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Call your doctor at once if you have a serious side effect such as:

  • chest pain, shortness of breath, feeling like you might pass out;
  • easy bruising or bleeding, unusual weakness; or
  • extreme thirst with headache, nausea, vomiting, and weakness.

Less serious side effects may include:

  • dizziness or weakness;
  • headache, tired feeling;
  • mild nausea, heartburn, full feeling;
  • skin rash, redness, or itching; or
  • increased skin sensitivity to sunlight.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about tolazamide (Tolinase)?

Do not use this medication if you are allergic to tolazamide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.

Before taking tolazamide, tell your doctor if you have kidney or liver disease, or a history of heart disease.

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your tolazamide dose.

Tolazamide is only part of a complete program of treatment that may also include diet, exercise, weight control, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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