IN THIS ARTICLE
What should I discuss with my healthcare provider before taking tolcapone (Tasmar)?
You should not use this medication if you are allergic to tolcapone, or if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.
Serious or fatal side effects on the liver have occurred in some people taking tolcapone. You may be required to read and sign a Patient Consent form before you get a prescription for tolcapone.
You should not use tolcapone if you are allergic to it, or if you have:
If you have any of these other conditions, you may need a tolcapone dose adjustment or special tests:
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking tolcapone. It is not known whether the medicine actually causes this effect. Talk with your doctor if you believe you have any intense or unusual urges while taking tolcapone.
Tolcapone may cause hallucinations (the sensation of hearing or seeing something that is not there), most commonly among elderly people. Call your doctor if you experience hallucinations.
Some people taking Parkinson's disease medications have developed skin cancer (melanoma). However, people with Parkinson's disease may have a higher risk of melanoma. Talk to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.
FDA pregnancy category C. It is not known whether tolcapone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication..
It is not known whether tolcapone passes into breast milk or if it could harm a nursing baby. Do not take tolcapone without telling your doctor if you are breast-feeding a baby.
How should I take tolcapone (Tasmar)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Tolcapone must be taken together with carbidopa and levodopa. Tolcapone used alone will not treat symptoms of Parkinson's disease.
Your doctor may occasionally change your dose to make sure you get the best results.
Tolcapone is usually taken three times a day. The first dose is taken with your first daily dose of carbidopa and levodopa. The second and third doses of tolcapone are taken 6 and 12 hours later.
Tolcapone may be taken with or without food.
To be sure this medicine is not causing harmful effects, your blood will need to be tested often. Your liver and kidney function may also need to be tested. Visit your doctor regularly.
Call your doctor if your symptoms do not improve after 3 weeks of using tolcapone.
Do not stop using tolcapone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using tolcapone.
Store at room temperature in a tightly closed container, away from moisture and heat.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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