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What should I discuss with my healthcare provider before taking trazodone (Desyrel, Oleptro)?
Do not use this medication if you are allergic to trazodone.
Do not take trazodone if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days.
If you have any of these other conditions, you may need a trazodone dose adjustment or special tests:
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
FDA pregnancy category C. It is not known whether trazodone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Trazodone may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give trazodone to anyone younger than 18 years old without the advice of a doctor.
How should I take trazodone (Desyrel, Oleptro)?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
The Desyrel brand of trazodone should be taken after a meal or a snack.
Take the Oleptro brand of trazodone on an empty stomach at bedtime, unless your doctor tells you otherwise.
Do not crush or chew an extended-release tablet. Swallow it whole. Your doctor may want you to break an extended-release tablet and take only half of it. Follow your doctor's instructions.
It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 2 weeks of treatment.
Do not stop using trazodone suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using trazodone.
Store at room temperature away from moisture, heat, and light.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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