What happens if I miss a dose (Desyrel, Oleptro)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Desyrel, Oleptro)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).
Overdose symptoms may include drowsiness, vomiting, penis erection that is painful or prolonged, fast or pounding heartbeat, seizure (black-out or convulsions), or breathing that slows or stops.
What should I avoid while taking trazodone (Desyrel, Oleptro)?
Do not drink alcohol. Trazodone can increase the effects of alcohol, which could be dangerous.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Trazodone may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
What other drugs will affect trazodone (Desyrel, Oleptro)?
Ask your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with trazodone may cause you to bruise or bleed easily.
Before taking trazodone tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by trazodone.
Many drugs can interact with trazodone. Below is just a partial list. Tell your doctor if you are using:
- a blood thinner such as warfarin (Coumadin);
- digoxin (Lanoxin, Lanoxicaps);
- any other antidepressant, or a medication to treat psychiatric disorders;
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), levofloxacin (Levaquin), pentamidine (NebuPent, Pentam), and others;
- an antifungal medication such as ketoconazole (Extina, Ketozole, Nizoral, Xolegal), itraconazole (Sporanox), or voriconazole (Vfend);
- anti-malaria medications such as chloroquine (Arelan), or mefloquine (Lariam);
- heart or blood pressure medication such as diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
- heart rhythm medicine such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), procainamide (Pronestyl), quinidine (Quin-G), and others;
- HIV/AIDS medicine such as fosamprenavir (Lexiva), indinavir (Crixivan), ritonavir (Norvir), and others;
- medicine to prevent or treat nausea and vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran);
- migraine headache medicine such as sumatriptan (Imitrex);
- narcotic medication such as methadone (Dolophine, Methadose); or
- seizure medicine such as carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin).
This list is not complete and there are many other drugs that can interact with trazodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Where can I get more information?
Your pharmacist can provide more information about trazodone.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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