What happens if I miss a dose (Artane, Trihexane)?
Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.
What happens if I overdose (Artane, Trihexane)?
Seek emergency medical attention.
Symptoms of a trihexyphenidyl overdose include large pupils; warm, dry skin; flushed face; fever; dry mouth; fast or irregular heartbeat; anxiety; hallucinations; confusion; agitation; hyperactivity; loss of consciousness; and seizures.
What should I avoid while taking trihexyphenidyl (Artane, Trihexane)?
Use caution when driving, operating machinery, or performing other hazardous activities. Trihexyphenidyl may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking trihexyphenidyl.
Avoid becoming overheated. Trihexyphenidyl may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness.
What other drugs will affect trihexyphenidyl (Artane, Trihexane)?
Before taking this medication, tell your doctor if you are taking any of the following medicines:
- a tricyclic antidepressant (used to treat depression, pain, or obsessive-compulsive disorder) such as amitriptyline (Elavil, Endep), doxepin (Sinequan), clomipramine (Anafranil), amoxapine (Asendin), desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), or protriptyline (Vivactil);
- a phenothiazine (used to treat mania, schizophrenia, other psychiatric conditions, and nausea and vomiting) such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), promazine (Sparine), trifluoperazine (Stelazine), and others;
- thiothixene (Navane) or chlorprothixene (Taractan);
- an antihistamine such as diphenhydramine (Benadryl, others), chlorpheniramine (Chlor-Trimeton, others), triprolidine (Actifed, others), brompheniramine (Dimetapp, others), clemastine (Tavist), and others (antihistamines are often found in prescription and over-the-counter cold, allergy, and sleep medicines);
- quinidine (Quinora, Quinaglute, Quinidex, Cardioquin);
- amantadine (Symmetrel);
- digoxin (Lanoxin, Lanoxicaps); or
- haloperidol (Haldol).
You may not be able to take trihexyphenidyl or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with trihexyphenidyl. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
Where can I get more information?
Your pharmacist has more information about trihexyphenidyl written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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