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What should I discuss with my healthcare provider before taking tripelennamine (PBZ, PBZ-SR)?

Do not take tripelennamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• glaucoma or increased pressure in the eye;
• a stomach ulcer;
• an enlarged prostate, bladder problems, or difficulty urinating;
• an overactive thyroid (hyperthyroidism);
• high blood pressure or any type of heart problem; or
• asthma.

You may not be able to take tripelennamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether tripelennamine will be harmful to an unborn baby. Do not take tripelennamine without first talking to your doctor if you are pregnant.

Tripelennamine may be harmful to a nursing baby. Do not take tripelennamine without first talking to your doctor if you are breast-feeding.

If you are over 60 years of age, you may be more likely to experience side effects from tripelennamine. You may require a lower dose of this medication.

How should I take tripelennamine (PBZ, PBZ-SR)?

Take tripelennamine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Tripelennamine can be taken with food to lessen stomach upset.

Do not crush, chew, or break the sustained-release forms of tripelennamine. Swallow them whole. They are specially formulated to release slowly in the body.

To ensure that you get a correct dose, measure the elixir form of tripelennamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of this medication than is prescribed for you. The regular-release tablets can be taken up to six times per day (every 4 hours) to a maximum of 600 mg for adults. The sustained-release tablets can be taken two or three times per day (every 8 to 12 hours) to a maximum of 300 mg for adults.

Store tripelennamine at room temperature away from moisture and heat.

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