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What should I discuss with my health care provider before receiving tromethamine (Tham)?

You should not receive this medication if you have uremia (urea circulating in your blood) or if you are unable to urinate (such as due to kidney failure).

If possible, before you receive tromethamine, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• congestive heart failure; or
• asthma or other breathing problems.

If you have any of these conditions, you may not be able to receive tromethamine, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether tromethamine passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

In an emergency situation, it may not be possible before you are treated with tromethamine to tell your caregivers about any health conditions you have or if you are pregnant or breast-feeding. However, make sure any doctor caring for your pregnancy or your baby knows that you have received this medication.

How is tromethamine given (Tham)?

Tromethamine is given as an injection under the skin or into a muscle. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion.

Tromethamine is often given for only a short period of time, such as one day. The length of time you receive treatment will depend on how your body responds to the medication.

To be sure this medication is not causing harmful effects, your blood and heart function will need to be checked throughout your treatment.

After treatment with tromethamine, you will be closely watched and tested to make sure the medication has been effective and you no longer have any effects of metabolic acidosis.

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