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vorinostat (cont.)

What should I discuss with my health care provider before taking vorinostat (Zolinza)?

You should not use this medication if you are allergic to vorinostat, or if you have severe liver disease.

To make sure vorinostat is safe for you, tell your doctor if you have any of these other conditions:

  • diabetes;
  • liver disease;
  • kidney disease;
  • anemia (low red blood cells);
  • an electrolyte imbalance (such as high or low potassium levels in your blood);
  • a personal or family history of Long QT syndrome;
  • a history of stroke or blood clot; or
  • if you have recently been ill with vomiting or diarrhea.

FDA pregnancy category D. Do not use vorinostat if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether vorinostat passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using vorinostat.

How should I take vorinostat (Zolinza)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results. Follow the directions on your prescription label.

Vorinostat is usually taken once daily with food.

Drink at least 2 liters of water each day to keep from getting dehydrated while you are taking vorinostat. Tell your doctor if you have severe vomiting or diarrhea during treatment.

Do not crush or open a vorinostat capsule. Swallow it whole. The medicine inside the capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If this occurs, wash your skin with soap and water or rinse your eyes with water. Ask your doctor or pharmacist how to safely handle and dispose of a broken capsule.

You will need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly.

Store at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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