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May 16, 2012
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Drug Allergy

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Drug Allergy Overview

Allergic reaction is an uncommon and unwanted side effect of medication.

Several different types of allergic reactions to medications can occur. Reactions to drugs range from a mild localized rash to serious effects on vital systems. The body's response can affect many organ systems, but the skin is the organ most frequently involved.

It is important to recognize the symptoms of a drug allergy, because they can be life-threatening. Death from an allergic reaction to a medication is extremely rare, however.

An allergic reaction does not often happen the first time you take a medication. A reaction is much more likely to occur the next time you take that medication. If you have a reaction the first time, you probably were exposed to the medication before without being aware of it.

Not all adverse reactions to drugs are allergies. In fact, fewer than 10% of adverse drug reactions are allergic. Other causes of adverse reactions are interactions between two or more drugs, inability to break the drug down completely in the body (as occurs with liver or kidney damage), overdose, and irritating side effects such as nausea, vomiting, or diarrhea. If you have experienced a nonallergic drug reaction, it is important to describe it as such to medical personnel-not as an allergy. If you don't know just describe the reaction the best way that you can.

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Drug Allergy - Experience

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Drug Allergy

Life-Threatening Skin Rashes Overview

Rashes are very common conditions and can have many causes. Most rashes are not dangerous but rather are merely nuisances. Life-threatening skin rashes are rare, but when they do occur, you must identify them and go to a doctor quickly.

Five potentially life-threatening disorders that have skin rash as the primary symptom are pemphigus vulgaris (PV), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), toxic shock syndrome (TSS), and staphylococcal scalded skin syndrome (SSSS). Signs of these life-threatening rashes include rash that affects the entire body and blisters. Accordingly, all of these diseases have one or more of the following features:

  • The rash affects the entire body, or most of it. Rash affects both the skin and the mucous membranes. Mucous membranes are the moist linings of the following:
    • Mouth and nose
    • Eyes
    • Anus/rectum
    • Vagina...

Read the Life-Threatening Skin Rashes article »


Read What Your Physician is Reading on Medscape

Drug Eruptions »

Drug eruptions can mimic a wide range of dermatoses. The morphologies are myriad and include morbilliform (most common, see Media file 1), urticarial, papulosquamous, pustular, and bullous. Medications can also cause pruritus and dysesthesia without an obvious eruption.

Read More on Medscape Reference »

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