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Epa (Eicosapentaenoic Acid)

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Are there any interactions with medications?



Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

EPA can decrease blood pressure. Taking EPA along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

EPA (eicosapentaenoic acid) might slow blood clotting. Taking EPA (eicosapentaenoic acid) along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Dosing considerations for Epa (eicosapentaenoic Acid).

EPA is usually administered with DHA (docosahexaenoic acid) as fish oil. A wide range of doses have been used. A typical dose is 5 grams of fish oil containing 169-563 mg of EPA and 72-312 mg of DHA.
  • For depression: 1 gram EPA twice daily.
  • For borderline personality disorder: 1 gram of EPA daily (as ethyl eicosapentaenoic acid) has been used for up to 8 weeks.
  • For symptoms of menopause such as hot flashes: 500 mg ethyl-EPA three times daily has been used for up to 8 weeks.
Many fatty acid preparations such as EPA also contain small amounts of vitamin E as an antioxidant to prevent spoilage.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.



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