Evodia

Are there any interactions with medications?

---

Caffeine
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down caffeine to get rid of it. Evodia might increase how quickly the body gets rid of caffeine. Taking evodia along with caffeine might decrease the effects of caffeine.

---

Medications changed by the liver (Cytochrome P450 1A2 [CYP1A2] substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Evodia might increase how quickly the liver breaks down some medications. Taking evodia along with these medications might decrease how well the medications work.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.

---

Medications changed by the liver (Cytochrome P450 3A4 [CYP3A4] substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Evodia might decrease how quickly the liver breaks down some medications. Taking evodia along with these medications might increase the effects and side effects of these medications.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

---

Medications that change the liver (Cytochrome P450 1A2 [CYP1A2] inhibitors)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications decrease how well the liver breaks down other medications. These medications that change the liver might decrease how fast chemicals in evodia are broken down in the body. This might increase the effects and side effects of evodia.

---

Medications that slow blood clotting (Anticoagulant/Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Evodia might slow blood clotting. Taking evodia along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

---

Theophylline
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

The body breaks down theophylline to get rid of it. Evodia might increase how quickly the body gets rid of theophylline. Taking evodia along with theophylline might decrease the effectiveness of theophylline.

Dosing considerations for Evodia.

The appropriate dose of evodia depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for evodia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.