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Gamma Butyrolactone (Gbl)

IN THIS ARTICLE

Are there any interactions with medications?



Alcohol
Interaction Rating: Major Do not take this combination.

Alcohol can cause sleepiness and drowsiness. Taking GBL along with alcohol might greatly increase sleepiness and drowsiness caused by alcohol. Taking GBL along with alcohol can lead to serious side effects. Do not take GBL if you have been drinking.



Amphetamines
Interaction Rating: Major Do not take this combination.

Amphetamines are drugs that can speed up your nervous system. GBL is changed in the body to GHB (gamma hydroxybutyrate). GHB can slow down your nervous system. Taking GBL along with amphetamines can lead to serious side effects.



Haloperidol (Haldol)
Interaction Rating: Major Do not take this combination.

GBL can affect the brain. Haloperidol (Haldol) can also affect the brain. Taking haloperidol (Haldol) along with GBL might cause serious side effects.



Medications for mental conditions (Antipsychotic drugs)
Interaction Rating: Major Do not take this combination.

GBL can affect the brain. Medications for mental conditions also affect the brain. Taking GBL along with medications for mental conditions might increase the effects and serious side effects of GBL. Do not take GBL if you are taking medications for a mental condition.

Some of these medications include fluphenazine (Permitil, Prolixin), haloperidol (Haldol), chlorpromazine (Thorazine), prochlorperazine (Compazine), thioridazine (Mellaril), trifluoperazine (Stelazine), and others.



Medications for pain (Narcotic drugs)
Interaction Rating: Major Do not take this combination.

Some medications for pain can cause sleepiness and drowsiness. GBL might also cause sleepiness and drowsiness. Taking GBL along with some medications for pain might cause severe side effects. Do not take GBL if you are taking medications for pain.

Some medications for pain include meperidine (Demerol), hydrocodone, morphine, OxyContin, and many others.



Medications used to prevent seizures (Anticonvulsants)
Interaction Rating: Major Do not take this combination.

Medications used to prevent seizures affect chemicals in the brain. GBL is changed in the body to one of these brain chemicals called GABA. Taking GBL along with medications used to prevent seizures might decrease the effects of GBL.

Some medications used to prevent seizures include phenobarbital, primidone (Mysoline), valproic acid (Depakene), gabapentin (Neurontin), carbamazepine (Tegretol), phenytoin (Dilantin), and others.



Muscle relaxants
Interaction Rating: Major Do not take this combination.

Muscle relaxants can cause drowsiness. GBL can also cause drowsiness. Taking GBL along with muscle relaxants might cause too much drowsiness and serious side effects. Do not take GBL if you are taking muscle relaxants.

Some of these muscle relaxants include carisoprodol (Soma), pipecuronium (Arduan), orphenadrine (Banflex, Disipal), cyclobenzaprine, gallamine (Flaxedil), atracurium (Tracrium), pancuronium (Pavulon), succinylcholine (Anectine), and others.



Naloxone (Narcan)
Interaction Rating: Major Do not take this combination.

GBL is changed by the body to another chemical. This chemical is called GHB. GHB can affect the brain. Taking naloxone (Narcan) along with GBL might decrease the effects of GBL on the brain.



Ritonavir (Norvir)
Interaction Rating: Major Do not take this combination.

Ritonavir (Norvir) and saquinavir (Fortovase, Invirase) are commonly used together for HIV/AIDS. Taking both of these medications plus GBL might decrease how quickly the body gets rid of GBL. This could cause serious side effects.



Saquinavir (Fortovase, Invirase)
Interaction Rating: Major Do not take this combination.

Saquinavir (Fortovase, Invirase) and ritonavir (Norvir) are commonly used together for HIV/AIDS. Taking both these medications plus GBL might decrease how fast the body gets rid of GBL. This could cause serious side effects.



Sedative medications (Benzodiazepines)
Interaction Rating: Major Do not take this combination.

GBL might cause sleepiness and drowsiness. Medications that cause sleepiness and drowsiness are called sedatives. Taking GBL along with sedative medications might cause serious side effects. Do not take GBL if you are taking sedative medications.

Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.



Sedative medications (CNS depressants)
Interaction Rating: Major Do not take this combination.

GBL might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking GBL along with sedative medications might cause serious side effects. Do not take GBL if you are taking sedative medications.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Dosing considerations for Gamma Butyrolactone (gbl).

The appropriate dose of gamma butyrolactone (GBL) depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for gamma butyrolactone (GBL). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.






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