glimepiride, Amaryl Glossary of Terms

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Abnormal: Outside the expected norm, or uncharacteristic of a particular patient.

Allergic reaction: The hypersensitive response of the immune system of an allergic individual to a substance.
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Blood pressure: The blood pressure is the pressure of the blood within the arteries. It is produced primarily by the contraction of the heart muscle. It's measurement is recorded by two numbers. The first (systolic pressure) is measured after the heart contracts and is highest. The second (diastolic pressure) is measured before the heart contracts and lowest. A blood pressure cuff is used to measure the pressure. Elevation of blood pressure is called "hypertension".

Blood sugar: Blood glucose. See also: High blood sugar; Low blood sugar.

Blurred vision: Lack of sharpness of vision with, as a result, the inability to see fine detail. Blurred vision can occur when a person who wears corrective lens is without them. Blurred vision can also be an important clue to eye disease.

Diabetes: Refers to diabetes mellitus or, less often, to diabetes insipidus. Diabetes mellitus and diabetes insipidus share the name "diabetes" because they are both conditions characterized by excessive urination (polyuria).
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Dizziness: Painless head discomfort with many possible causes including disturbances of vision, the brain, balance (vestibular) system of the inner ear, and gastrointestinal system. Dizziness is a medically indistinct term which laypersons use to describe a variety of conditions ranging from lightheadedness, unsteadiness to vertigo.
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Enzymes: Proteins that act as a catalysts in mediating and speeding a specific chemical reaction.

FDA: Food and Drug Administration.

Fetus: An unborn offspring, from the embryo stage (the end of the eighth week after conception, when the major structures have formed) until birth.

Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Headache: A pain in the head with the pain being above the eyes or the ears, behind the head (occipital), or in the back of the upper neck. Headache, like chest pain or back ache, has many causes.
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Heart: The muscle that pumps blood received from veins into arteries throughout the body. The heart is positioned in the chest behind the sternum (breastbone); in front of the trachea, esophagus, and aorta; and above the diaphragm. A normal heart is about the size of a closed fist and weighs about 298 grams or 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest, with the balance in the right side of the chest. The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an anatomically separate left atrium and ventricle. The blood flows from the systemic veins into the right atrium, thence to the right ventricle, from which it is pumped to the lungs and then returned into the left atrium, thence to the left ventricle, from which it is driven into the systemic arteries. The heart is thus functionally composed of two hearts: the right heart and the left heart. The right heart consists of the right atrium, which receives deoxygenated blood from the body, and the right ventricle, which pumps the deoxygenated blood to the lungs under low pressure; and the left heart, which consists of the left atrium, which receives oxygenated blood from the lung, and the left ventricle, which pumps the oxygenated blood out to the body under high pressure.

High blood pressure: A repeatedly elevated blood pressure exceeding 140 over 90 mmHg. Chronic high blood pressure can stealthily cause blood vessel changes in the back of the eye (retina), abnormal thickening of the heart muscle, kidney failure, and brain damage. No specific cause for high blood pressure is found in 95 percent of patients. Treatment for high blood pressure involves dietary changes, regular aerobic exercise, and medication. There are many types of medications used to treat high blood pressure including diuretics, beta-blockers, blood vessel dilators, and others. Also known as hypertension.

Hypoglycemia: Low blood sugar (glucose). Hypoglycemia may be associated with symptoms such as anxiety, sweating, tremor, palpitations, nausea, and pallor. Hypoglycemia also starves the brain of glucose energy, which is essential for proper brain function. Lack of glucose energy to the brain can cause symptoms ranging from headache, mild confusion, abnormal behavior, loss of consciousness, seizure, and coma. Severe hypoglycemia can cause death. The causes of hypoglycemia include use of drugs (such as insulin), liver disease, surgical absence of the stomach, tumors that release excess amounts of insulin, and pre-diabetes. In some patients, symptoms of hypoglycemia occur during fasting (fasting hypoglycemia). In others, symptoms of hypoglycemia occur after meals (reactive hypoglycemia). Immediate treatment of severe hypoglycemia consists of administering large amounts of glucose and repeating this treatment at intervals if the symptoms persist. Treatment must also be directed at the underlying cause. Treatment of reactive hypoglycemia involves changing the diet, including eating fewer concentrated sweets and ingesting multiple small meals throughout the day.

Infant: A young baby, from birth to 12 months of age.

Insulin: A natural hormone made by the pancreas that controls the level of the sugar glucose in the blood. Insulin permits cells to use glucose for energy. Cells cannot utilize glucose without insulin.
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Kidney: One of a pair of organs located in the right and left side of the abdomen. The kidneys remove waste products from the blood and produce urine. As blood flows through the kidneys, the kidneys filter waste products, chemicals, and unneeded water from the blood. Urine collects in the middle of each kidney, in an area called the renal pelvis. It then drains from the kidney through a long tube, the ureter, to the bladder, where it is stored until elimination. The kidneys also make substances that help control blood pressure and regulate the formation of red blood cells.

Liver: The largest solid organ in the body, situated in the upper part of the abdomen on the right side. The liver has a multitude of important and complex functions, including to manufacture proteins, including albumin (to help maintain the volume of blood) and blood clotting factors; to synthesize, store, and process fats, including fatty acids (used for energy) and cholesterol; to metabolize and store carbohydrates (used as the source for the sugar in blood); to form and secrete bile that contains bile acids to aid in the intestinal absorption of fats and the fat-soluble vitamins A, D, E, and K; to eliminate, by metabolizing or secreting, the potentially harmful biochemical products produced by the body, such as bilirubin, from the breakdown of old red blood cells and ammonia from the breakdown of proteins; and to detoxify, by metabolizing and/or secreting, drugs, alcohol, and environmental toxins.

Low blood sugar: A low blood level of the sugar glucose. Also called hypoglycemia.
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Mouth: 1. The upper opening of the digestive tract, beginning with the lips and containing the teeth, gums, and tongue. Foodstuffs are broken down mechanically in the mouth by chewing and saliva is added as a lubricant. Saliva contains amylase, an enzyme that digests starch. 2. Any opening or aperture in the body. The mouth in both senses of the word is also called the os, the Latin word for an opening, or mouth. The o in os is pronounced as in hope. The genitive form of os is oris from which comes the word oral.

Muscle: Muscle is the tissue of the body which primarily functions as a source of power. There are three types of muscle in the body. Muscle which is responsible for moving extremities and external areas of the body is called "skeletal muscle." Heart muscle is called "cardiac muscle." Muscle that is in the walls of arteries and bowel is called "smooth muscle."

Nausea: Stomach queasiness, the urge to vomit. Nausea can be brought on by many causes, including systemic illnesses (such as influenza), medications, pain, and inner ear disease.

Nerve: A bundle of fibers that uses electrical and chemical signals to transmit sensory and motor information from one body part to another. The fibrous portions of a nerve are covered by a sheath called myelin and/or a membrane called neurilemma. (Note that entries for specific nerves can be found under the names of the particular nerves. For example, the optic nerve is not under 'nerve, optic' but rather under 'optic nerve.')

Niacin: Nicotinic acid, one of the B-complex B vitamins. Deficiency of niacin in the diet results in the disease pellagra. See: Pellagra.

Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

Palpitations: Unpleasant sensations of irregular and/or forceful beating of the heart. In some patients with palpitations, no heart disease or abnormal heart rhythms can be found. In others, palpitations result from abnormal heart rhythms (arrhythmias).

Pancreas: A spongy, tube-shaped organ that is about 6 inches long and is located in the back of the abdomen, behind the stomach. The head of the pancreas is on the right side of the abdomen. It is connected to the upper end of the small intestine. The narrow end of the pancreas, called the tail, extends to the left side of the body. The pancreas makes pancreatic juices and hormones, including insulin and secretin. Pancreatic juices contain enzymes that help digest food in the small intestine. Both pancreatic enzymes and hormones are needed to keep the body working correctly. As pancreatic juices are made, they flow into the main pancreatic duct, which joins to the common bile duct, which connects the pancreas to the liver and the gallbladder and carries bile to the small intestine near the stomach. The pancreas is thus a compound gland in the sense that it is composed of both exocrine and endocrine tissues. The exocrine function of the pancreas involves the synthesis and secretion of pancreatic juices. The endocrine function resides in the million or so cellular islands (the islets of Langerhans) that are embedded between the exocrine units of the pancreas. Beta cells of the islets of Langerhans secrete insulin, which helps control carbohydrate metabolism. Alpha cells of the islets of Langerhans secrete glucagon, which counters the action of insulin.

Perspiration: 1) The secretion of fluid by the sweat (sudoriferous) glands. These small, tubular glands are situated within the skin, as well as in the subcutaneous tissue under it. They discharge their fluid through tiny openings in the surface of the skin. Perspiration serves at least two purposes: the removal of waste products such as urea and ammonia, and cooling of the body temperature as sweat evaporates. 2) The transparent, colorless, acidic fluid secreted by the sweat glands. It contains some fatty acids and mineral matter. Adult perspiration gains its characteristic odor from the waste products excreted. Also known as sweat.

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
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Pregnant: The state of carrying a developing fetus within the body.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Rash: Breaking out (eruption) of the skin. A rash can be caused by an underlying medical condition, hormonal cycles, allergies, or contact with irritating substances. Treatment depends on the underlying cause of the rash. Medically, a rash is referred to as an exanthem.

Resistance: Opposition to something, or the ability to withstand something. For example, some forms of the staphylococcus bacterium are resistant to treatment with antibiotics.

Sulfonylurea: A class of oral hypoglycemic agents (medications that lower the level of blood glucose) taken by people with type 2 diabetes. The sulfonylureas increase the secretion of insulin by the pancreas. There are two generations of sulfonylureas. The main difference between the first- and second-generation sulfonylureas is in the way they are 'eliminated from the body. As a consequence, second-generation sulfonylureas are usually taken less 'frequently each day than first-generation sulfonylureas and generally are preferred when there is poor function of the kidneys. Examples of first-'generation sulfonylureas are chlorpropamide (Diabinese) and tolbutamide (Orinase). The second-generation sulfonylureas include glipizide (Glucotrol and Glucotrol XL), glyburide (Diabeta, Micronase, and Glynase PresTab), and glimepiride (Amaryl). These drugs are effective in rapidly 'lowering blood sugar but run the risk of causing hypoglycemia.

Tenormin: See: Atenolol.

Therapy: The treatment of disease. Therapy is synonymous with treatment.

Tiredness: See: Tired.

Yawning: Involuntary opening of the mouth with respiration, breathing first inward, then outward. Yawning is often caused by the power of suggestion. Repeated yawning may be a sign of drowsiness. It can also sometimes be a sign of depression.