Medications and Drugs
Brand Names: Glucovance
Generic Name: glyburide and metformin (Pronunciation: GLYE bure ide and met FOR min)
What is glyburide and metformin (Glucovance)?
Glyburide and metformin may also be used for purposes not listed in this medication guide.
Glucovance 1.25 mg-250 mg
oblong, yellow, imprinted with BMS, 6072
Glucovance 2.5 mg-500 mg
oblong, orange, imprinted with BMS, 6073
Glucovance 5 mg-500 mg
oblong, yellow, imprinted with BMS, 6074
GlyBURIDE-Metformin 1.25 mg-250 mg-GG
round, yellow, imprinted with cor 140
Glyburide-Metformin 1.25-250 mg-IVA
oblong, yellow, imprinted with LOGO 5710, 1.25/250
GlyBURIDE-Metformin 2.5 mg-500 mg-GG
round, orange, imprinted with cor 141
Glyburide-Metformin 2.5-500 mg-IVA
oblong, orange, imprinted with LOGO 5711, 2.5/500
GlyBURIDE-Metformin 5 mg-500 mg-GG
round, yellow, imprinted with cor 142
Glyburide-Metformin 5-500 mg-IVA
oval, yellow, imprinted with LOGO 5712, 5/500
What are the possible side effects of glyburide and metformin (Glucovance)?
This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have a serious side effect such as:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about glyburide and metformin (Glucovance)?
You should not use this medication if you are allergic to glyburide or metformin, or if you have kidney disease or are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking glyburide and metformin.
Before you take this medication, tell your doctor if you have liver or heart disease, a history of heart attack or stroke, or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).
Some people develop lactic acidosis while taking glyburide and metformin. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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