Medications

If you still have heartburn symptoms after lifestyle modifications and use of antacids, your health care provider may prescribe drugs.

• The next group of drugs to be tried is called histamine-2 blockers. Examples include ranitidine (Zantac), cimetidine (Tagamet), famotidine (Pepcid), and nizatidine (Axid). These tablets decrease the amount of acid your stomach produces. Many of these drugs can be bought over-the-counter at low doses but need a doctor's prescription for higher doses. They provide relief of symptoms within 30 minutes and are taken twice a day.
  
  
• If you continue to have heartburn, the doctor may recommend adding a drug such as metoclopramide (Reglan). This type of drug empties food and acid quickly from the stomach so less can travel back into the esophagus. Reglan also helps tighten the LES muscle.
  
  
• If you still have symptoms, the doctor will then recommend drugs called proton pump inhibitors. Examples of these drugs include omeprazole (Prilosec), lansoprazole (Prevacid), esomeprazole (Nexium), and pantoprazole (Protonix). These compounds prevent the stomach from secreting acid. They are very effective and are typically taken only once a day. These drugs are usually only prescribed if other drugs have not helped.