Hemochromatosis (Iron Overload) (cont.)
The outlook for hereditary hemochromatosis is favorable if it is diagnosed early and treated promptly. Life expectancy, in general, is a significantly improved survival rate with removal of excess iron and its maintenance in the normal range.
The main causes of death in untreated patients with hemochromatosis are heart failure, cirrhosis of the liver, and liver cancer.
Medically reviewed by Martin E Zipser, MD; American board of Surgery
Edwards, CQ, Kushner, JP. Screening for hemochromatosis. N Engl J Med 1993: 328:1616.
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Milward, EA, Baines, SK, Knuiman, MW, et al. Noncitrus Fruits as Novel
Dietary Environmental Modifiers of Iron Stores in People With or Without HFE
Gene Mutations. Mayo Clin Proc 2008; 83:543.
Fletcher, LM, Dixon, JL, Purdie, DM, Powell, LW. Excess
Alcohol Greatly Increases the Prevalence of Cirrhosis in Hereditary
Hemochromatosis. Gastroenterology 2002; 122:281.
Edwards, CQ, Griffen, LM, Goldgar, D, et al. Prevalence of hemochromatosis
among 11,065 presumably healthy blood donors. N Engl J Med 1988; 318:1355.
Phatak, P, Bonkovsky, HL, Kowdley, K. Hereditary
Hemochromatosis: Time for targeted screening. Ann Intern Med. 2008;149:270-272.
Harrison's Principles on Internal Medicine, 1998
Medically Reviewed by a Doctor on 6/20/2014
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