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Hemochromatosis (Iron Overload) (cont.)


The outlook for hereditary hemochromatosis is favorable if it is diagnosed early and treated promptly. Life expectancy, in general, is a significantly improved survival rate with removal of excess iron and its maintenance in the normal range.

The main causes of death in untreated patients with hemochromatosis are heart failure, cirrhosis of the liver, and liver cancer.

Medically reviewed by Martin E Zipser, MD; American board of Surgery


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Milward, EA, Baines, SK, Knuiman, MW, et al. Noncitrus Fruits as Novel Dietary Environmental Modifiers of Iron Stores in People With or Without HFE Gene Mutations. Mayo Clin Proc 2008; 83:543.
Fletcher, LM, Dixon, JL, Purdie, DM, Powell, LW. Excess Alcohol Greatly Increases the Prevalence of Cirrhosis in Hereditary Hemochromatosis. Gastroenterology 2002; 122:281.
Edwards, CQ, Griffen, LM, Goldgar, D, et al. Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med 1988; 318:1355.
Phatak, P, Bonkovsky, HL, Kowdley, K. Hereditary Hemochromatosis: Time for targeted screening. Ann Intern Med. 2008;149:270-272.
Harrison's Principles on Internal Medicine, 1998

Medically Reviewed by a Doctor on 6/20/2014

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