Hemochromatosis (Iron Overload) (cont.)
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Iron accumulation from hereditary hemochromatosis can affect many organs in the body, leading to a variety of possible symptoms. Many individuals with hemochromatosis may not have any symptoms or disease manifestations at all, especially early in the course of the disease or in those with heterozygous genes. Some heterozygotes (one C282Y with either H63D or S65C) may have mild iron overload without overt hemochromatosis.
Because the iron overload may occur over years, most men present with symptoms of hemochromatosis in the 5th or 6th decade of life. This may lag even longer in women by 10 to 20 years because of excess iron loss from menstruation during the premenopausal years.
Initial symptoms of hemochromatosis may be non-specific including:
The most commonly involved organs in hemochromatosis are the liver, pancreas, joints, skin, heart, testicles, and the thyroid gland. Some of the most common manifestations and symptoms of hemochromatosis are listed as follows:
One of the possible late manifestations of hereditary hemochromatosis is referred to as "bronze diabetes". This condition occurs when the disease involves the skin (bronze appearance) and the pancreas (diabetes).
Many of these conditions are commonly seen in the general population and are not related to hereditary hemochromatosis. In addition, they may be present in varying degrees in individuals with hemochromatosis. Because of these factors, delay in making the diagnosis of hereditary hemochromatosis is not uncommon.
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