Hepatitis B Treatment (cont.)
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Interferons for Hepatitis B
How interferons work
Interferons are naturally occurring proteins in the body that help the body's natural defense system fight viruses. Interferon alfa-2b and pegylated interferon alfa-2a are proteins specifically designed to attach to the surface of the hepatitis B virus. Once attached, the proteins start a cascade of events leading to increased viral cell death. Pegylated interferon works in the same way as interferon alfa-2b, but it has an added structure that enables it to stay in the body longer and does not need to be administered as often. For this reason, and because studies have shown increased effectiveness, pegylated interferon is usually the agent of choice when an interferon product is used.
Who should not use interferons?
Dosing of interferons
Interferons are administered by a subcutaneous injection into the thigh or abdomen at various dosage schedules. Interferon alfa-2b is approved for children as young as one year old as well as adults. Pegylated interferon alfa-2a is approved only in adults 18 years of age or older. While taking these medications, it is important to have routine blood work done to monitor for possible side effects.
Drug or food interactions of interferons
Side effects of interferons
Other common side effects include:
More serious side effects include:
Effectiveness of interferons
In patients who have hepatitis e antigen (HBeAg) in their blood, treatment with pegylated interferon eliminates the HBeAg and allows antibody formation in approximately 27% of patients. Treatment eliminates viral DNA from the blood in approximately 25% of patients with HBeAg. In patients who do not have HBeAg in their blood, treatment with pegylated interferon eliminates viral DNA from the blood 65% of the time. Again, viral DNA can rebound after the treatment is stopped.
Medically Reviewed by a Doctor on 7/7/2016
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