- Histoplasmosis is an infection caused by a dimorphic
fungus, Histoplasma capsulatum.
- Risk factors for histoplasmosis include
immunocompromised people and association with airborne particles containing the
fungi (caves containing bats, bird feces, construction sites).
- Symptoms of
histoplasmosis range from none to flu-like symptoms (fever, dry cough, chest
discomfort); severe infections may cause vision problems, mouth ulcers,
seizures, encephalopathy, and death.
- Seek medical care if symptoms of the flu or
pneumonia persist, especially in people with immunocompromised systems.
- Definitive diagnosis is made by culturing and identifying Histoplasma capsulatum
from biopsy, blood, or sputum samples.
- The majority of patients infected by
Histoplasma capsulatum require no treatment; the small number of patients
develop more severe infection may require long-term antifungal treatments
(months to a year) while a few may need lifelong antifungal treatment.
- Follow-up is important because of the potential need for long-term antifungal
treatments to monitor drug levels and to determine effective treatment or
reoccurrence of infection.
- The large majority of patients who develop
histoplasmosis have no complication; ocular problems, mouth ulcers,
encephalopathy, seizures, and, rarely, death may occur those few patients that
develop severe disease.
- The large majority of people who develop histoplasmosis
have good outcomes; patients who are immunocompromised have outcomes that range
from good to poor, depending on their response to treatment and disease severity.
- No vaccine is currently available to prevent histoplasmosis; avoidance of bat
and bird habitats and avoiding construction sites that may aerosolize the fungi
Picture of spores of Histoplasma capsulatum fungi; SOURCE: CDC
Patient Comments & Reviews
The eMedicineHealth doctors ask about Histoplasmosis: