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There is no vaccine to prevent histoplasmosis. The CDC recommends people "avoid areas with accumulations of bird or bat droppings, especially if you have a weakened immune system. Areas with accumulations of bird or bat droppings should be cleaned up by professional companies that specialize in the removal of hazardous waste." For those workers who may need to be in areas with high levels of fungi, the CDC has a book that addresses safety methods.
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