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Hormone Replacement and Osteoporosis (cont.)

Side Effects of ERT

Side effects of estrogen

Common nonemergency side effects of estrogen - Although they are not considered emergencies, talk to the doctor as soon as possible if any of the following are experienced:

  • Breast discomfort
  • Breast swelling or increased breast size
  • Bilateral swelling of the legs and feet (swelling on both the right and left sides of the body)
  • Rapid weight gain

Urgent side effects of estrogen - Call a doctor immediately if any of the following side effects are experienced and they don't go away or they become more severe:

  • Stomach bloating or cramps
  • Decreased appetite
  • Nausea; vomiting; fever; or pain, swelling, or tenderness in the upper right abdomen may indicate liver or gall bladder problems
  • Prolonged or persistent vaginal bleeding or spotting
  • Breast lumps or discharge
  • Abdominal pain (may indicate liver or gall bladder problems)
  • Yellow skin or eyes (may indicate liver toxicity)
  • Calf pain and/or swelling (may indicate a blood clot)
  • Chest pain or shortness of breath
  • Mild diarrhea
  • Mild dizziness
  • Mild headache or migraine
  • Difficulty with contact lenses (lens prescription needs adjustment)
  • Increased sexual desire
  • Occasional vomiting

Side effects of progestin

Emergency side effects - Call the doctor immediately if any of the following side effects are experienced:

  • Difficulty breathing
  • Severe headache
  • Change or loss of vision
  • Severe depression
  • Dizziness
  • Weakness or numbness in an arm or leg
  • Calf pain and/or swelling (may indicate a blood clot)
  • Chest pain
  • Unexplained coughing or coughing blood
  • Yellow skin or eyes

Less urgent side effects - Call the doctor if any of the following side effects become severe or simply don't seem to be going away:

  • Breakthrough bleeding between menstrual periods
  • Noticeable changes in menstruation
  • Absent menstruation
  • Bloating
  • Noticeable weight changes
  • Darkening patches of skin
  • Acne
  • Fatigue
  • Indigestion
  • Breast pain
Medically Reviewed by a Doctor on 8/18/2014
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