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Hormone Replacement and Osteoporosis (cont.)

Side Effects of ERT

Side effects of estrogen

  • Common nonemergency side effects of estrogen - Although they are not considered emergencies, talk to the doctor as soon as possible if any of the following are experienced:
    • Breast discomfort
    • Breast swelling or increased breast size
    • Bilateral swelling of the legs and feet (swelling on both the right and left sides of the body)
    • Rapid weight gain
  • Urgent side effects of estrogen - Call a doctor immediately if any of the following side effects are experienced and they don't go away or they become more severe:
    • Stomach bloating or cramps
    • Decreased appetite
    • Nausea; vomiting; fever; or pain, swelling, or tenderness in the upper right abdomen may indicate gall bladder toxicity
    • Prolonged or persistent vaginal bleeding or spotting
    • Breast lumps or discharge
    • Abdominal pain (may indicate liver or gall bladder toxicity)
    • Yellow skin or eyes (may indicate liver toxicity)
    • Calf pain and/or swelling (may indicate a blood clot)
    • Chest pain or shortness of breath
    • Mild diarrhea
    • Mild dizziness
    • Mild headache or migraine
    • Difficulty with contact lenses (lens prescription needs adjustment)
    • Increased sexual desire
    • Occasional vomiting

Side effects of progestin

  • Emergency side effects - Call the doctor immediately if any of the following side effects are experienced:
    • Difficulty breathing
    • Severe headache
    • Change or loss of vision
    • Severe depression
    • Dizziness
    • Weakness or numbness in an arm or leg
    • Calf pain and/or swelling (may indicate a blood clot)
    • Chest pain
    • Unexplained coughing or coughing blood
    • Yellow skin or eyes

Less urgent side effects - Call the doctor if any of the following side effects become severe or simply don't seem to be going away:

  • Breakthrough bleeding between menstrual periods
  • Noticeable changes in menstruation
  • Absent menstruation
  • Bloating
  • Noticeable weight changes
  • Darkening patches of skin
  • Acne
  • Fatigue
  • Indigestion
  • Breast pain
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