How Nitrates Treat Systolic Heart Failure
Nitrates are medicines that act as vasodilators because they mimic the effect of one of the body's own natural chemicals called nitric oxide, which causes arteries and veins to widen (dilate).
Nitrates can improve heart failure symptoms by:
How well do nitrates work?
If you take hydralazine with a nitrate, you will also take other medicines for heart failure such as ACE inhibitors and beta-blockers. This combination of medicines may help relieve symptoms and lower the risk of early death. This benefit has been shown in African Americans but has not been shown in other groups of people.1
Vasodilators are often combined with other medicines to treat heart failure. Hydralazine taken with a nitrate may be used as an alternative to angiotensin-converting enzyme (ACE) inhibitors if ACE inhibitors cannot be tolerated.
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