Huntington Disease Dementia (cont.)
IN THIS ARTICLE
Huntington Disease Dementia Causes
Huntington disease is a hereditary disease. This means it is passed down in families from one generation to the next via an abnormal gene.
Genes are made up of DNA (deoxyribonucleic acid). DNA molecules are made up of building blocks called bases. The 4 bases are adenine, thymine, cytosine, and guanine, called A, T, C, and G for short.
The normal HD gene, which is located on chromosome 4, contains the base sequence CAG. The abnormal repetition of this sequence is known as the HD mutation.
Huntington disease is an autosomal dominant disorder. This means that the HD mutation takes precedence over the normal gene.
The HD gene directs production of a protein called huntington. This protein is found in neurons throughout the brain, but its normal function is unknown.
Medically Reviewed by a Doctor on 1/7/2015
Idan Sharon, MD
Nestor Galvez-Jimenez, MD
Francisco Talavera, PharmD, PhD
Helmi L Lutsep, MD
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