Huntington Disease Dementia (cont.)
Idan Sharon, MD
Nestor Galvez-Jimenez, MD
Francisco Talavera, PharmD, PhD
Helmi L Lutsep, MD
IN THIS ARTICLE
Huntington Disease Dementia Symptoms
Abnormal movements or emotional or behavioral changes are usually the earliest symptoms to appear in HD. Cognitive disturbances usually appear later in the course of the disease. Emotional, behavioral, and cognitive symptoms usually appear gradually and worsen over time.
The average life expectancy from onset of symptoms is about 15 years. Early onset of the disease, before age 20 years (juvenile HD), is linked to faster progression of symptoms and shorter life expectancy (approximately 8 years). Individuals who inherit the disease from their father tend to develop symptoms much earlier in life than those who inherit it from their mother.
Emotional and behavioral disturbances occur in 35-73% of people with HD.
Cognitive symptoms include the following:
Most people with HD retain their insight, factual knowledge, and intelligence quotient (IQ) score relatively well into the disease process. Use of language may or may not be impaired.
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