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Medications and Drugs

Brand Names: Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25

Generic Name: hydrochlorothiazide and captopril (Pronunciation: hye droe klor oh THY a zide and KAP toe pril)

What is hydrochlorothiazide and captopril (Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Captopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Captopril lowers blood pressure and also relieves symptoms of fluid retention.

The combination of hydrochlorothiazide and captopril is used to treat hypertension (high blood pressure).

Hydrochlorothiazide and captopril may also be used for purposes not listed in this medication guide.

Capozide 25-15 mg

square, white/orange specks, imprinted with CAPOZIDE 25/15

Captopril-HCTZ-25-15mg-MYL

round, white, imprinted with M 81

Captopril-HCTZ-25-25mg-MYL

round, peach, imprinted with M 83

Captopril-HCTZ-50-15mg-MYL

oblong, white, imprinted with M 84

Captopril-HCTZ-50-25mg-MYL

oblong, peach, imprinted with M 86

Captopril-Hydrochlorothiazide 25 mg-15 mg-TEV

round, white, imprinted with 93 176

Captopril-Hydrochlorothiazide 25 mg-25 mg-TEV

round, pink, imprinted with 93 177

Captopril-Hydrochlorothiazide 50 mg-15 mg-TEV

oval, white, imprinted with 93 181

Captopril-Hydrochlorothiazide 50 mg-25 mg-TEV

oval, white, imprinted with 93 182

What are the possible side effects of hydrochlorothiazide and captopril (Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • eye pain, vision problems;
  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • dry mouth, thirst, nausea, vomiting;
  • feeling weak, drowsy, restless, or light-headed;
  • a red, blistering, peeling skin rash;
  • jaundice (yellowing of the skin or eyes);
  • urinating less than usual or not at all;
  • swelling, weight gain, feeling short of breath; or
  • fever, chills, body aches, flu symptoms.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and captopril (Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25)?

You should not use this medication if you are allergic to hydrochlorothiazide or captopril, or if you have a history of asthma or allergies, or you are unable to urinate.

You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

Before taking hydrochlorothiazide and captopril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, glaucoma, congestive heart failure, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.

Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and captopril, unless your doctor has told you to.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and captopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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